Cancer Virus and Inflammation Research

16219459&query_hl=25">White MK, Khalili K.
Expression of JC virus regulatory proteins in human cancer: Potential mechanisms for tumorigenesis.
Eur J Cancer. 2005 Oct 7; [Epub ahead of print]
PMID:16219459

15982744&query_hl=25">White MK, Gordon J, Reiss K, Del Valle L, Croul S, Giordano A, Darbinyan A, Khalili K.
Human polyomaviruses and brain tumors.
Brain Res Brain Res Rev. 2005 Jun 24; [Epub ahead of print]
PMID:15982744

15630684&query_hl=25">Del Valle L, White MK, Enam S, Oviedo SP, Bromer MQ, Thomas RM, Parkman HP, Khalili K.
Detection of JC virus DNA sequences and expression of viral T antigen and agnoprotein in esophageal carcinoma.
Cancer. 2005 Feb 1;103(3):516-27.
PMID:15630684

11358858&query_hl=25">Del Valle L, Gordon J, Assimakopoulou M, Enam S, Geddes JF, Varakis JN, Katsetos CD, Croul S, Khalili K.
Detection of JC virus DNA sequences and expression of the viral regulatory protein T-antigen in tumors of the central nervous system.
Cancer Res. 2001 May 15;61(10):4287-93.
PMID:11358858

9776230&query_hl=25">Gordon J, Krynska B, Otte J, Houff SA, Khalili K.
Oncogenic potential of human neurotropic papovavirus, JCV, in CNS.
Dev Biol Stand. 1998;94:93-101. Review.
PMID:9776230

13129771&query_hl=25">O'Neill FJ, Greenlee JE, Dorries K, Clawson SA, Carney H.
Propagation of archetype and nonarchetype JC virus variants in human fetal brain cultures: demonstration of interference activity by archetype JC virus.
J Neurovirol. 2003 Oct;9(5):567-76.
PMID:13129771

9541611&query_hl=25">Sugimoto C, Ito D, Tanaka K, Matsuda H, Saito H, Sakai H, Fujihara K, Itoyama Y, Yamada T, Kira J, Matsumoto R, Mori M, Nagashima K, Yogo Y.
Amplification of JC virus regulatory DNA sequences from cerebrospinal fluid: diagnostic value for progressive multifocal leukoencephalopathy.
Arch Virol. 1998;143(2):249-62.
PMID:9541611

14987161&query_hl=25">Enam S, Sweet TM, Amini S, Khalili K, Del Valle L.
Evidence for involvement of transforming growth factor beta1 signaling pathway in activation of JC virus in human immunodeficiency virus 1-associated progressive multifocal leukoencephalopathy.
Arch Pathol Lab Med. 2004 Mar;128(3):282-91.
PMID:14987161

9852278&query_hl=25">Gordon J, Khalili K.
The human polyomavirus, JCV, and neurological diseases (review).
Int J Mol Med. 1998 Apr;1(4):647-55. Review.
PMID:9852278

9222341&query_hl=25">Atwood WJ, Wang L, Durham LC, Amemiya K, Traub RG, Major EO.
Evaluation of the role of cytokine activation in the multiplication of JC virus (JCV) in human fetal glial cells.
J Neurovirol. 1995 Mar;1(1):40-9.
PMID:9222341

15016869&query_hl=25">Del Valle L, Enam S, Lara C, Miklossy J, Khalili K, Gordon J.
Primary central nervous system lymphoma expressing the human neurotropic polyomavirus, JC virus, genome.
J Virol. 2004 Apr;78(7):3462-9.
PMID:15016869

10082081&query_hl=25">Tretiakova A, Krynska B, Gordon J, Khalili K.
Human neurotropic JC virus early protein deregulates glial cell cycle pathway and impairs cell differentiation.
J Neurosci Res. 1999 Mar 1;55(5):588-99.
PMID:10082081

12910255&query_hl=25">Khalili K, Del Valle L, Otte J, Weaver M, Gordon J.
Human neurotropic polyomavirus, JCV, and its role in carcinogenesis.
Oncogene. 2003 Aug 11;22(33):5181-91. Review.
PMID:12910255

11790878&query_hl=25">Khalili K.
Human neurotropic JC virus and its association with brain tumors.
Dis Markers. 2001;17(3):143-7. Review.
PMID:11790878

13129769&query_hl=25">Fedele CG, Ciardi MR, Delia S, Contreras G, Perez JL, De Ona M, Vidal E, Tenorio A.
Identical rearranged forms of JC polyomavirus transcriptional control region in plasma and cerebrospinal fluid of acquired immunodeficiency syndrome patients with progressive multifocal leukoencephalopathy.
J Neurovirol. 2003 Oct;9(5):551-8.
PMID:13129769

11854388&query_hl=25">Del Valle L, Gordon J, Enam S, Delbue S, Croul S, Abraham S, Radhakrishnan S, Assimakopoulou M, Katsetos CD, Khalili K.
Expression of human neurotropic polyomavirus JCV late gene product agnoprotein in human medulloblastoma.
J Natl Cancer Inst. 2002 Feb 20;94(4):267-73.
PMID:11854388

11238876&query_hl=25">Koralnik IJ, Du Pasquier RA, Letvin NL.
JC virus-specific cytotoxic T lymphocytes in individuals with progressive multifocal leukoencephalopathy.
J Virol. 2001 Apr;75(7):3483-7.
PMID:11238876

9754960&query_hl=25">Stoner GL, Ryschkewitsch CF.
Reappraisal of progressive multifocal leukoencephalopathy due to simian virus 40.
Acta Neuropathol (Berl). 1998 Sep;96(3):271-8.
PMID:9754960

12111355&query_hl=25">Okada Y, Sawa H, Endo S, Orba Y, Umemura T, Nishihara H, Stan AC, Tanaka S, Takahashi H, Nagashima K.
Expression of JC virus agnoprotein in progressive multifocal leukoencephalopathy brain.
Acta Neuropathol (Berl). 2002 Aug;104(2):130-6. Epub 2002 May 24.
PMID:12111355

8648759&query_hl=25">Chang CF, Gallia GL, Muralidharan V, Chen NN, Zoltick P, Johnson E, Khalili K.
Evidence that replication of human neurotropic JC virus DNA in glial cells is regulated by the sequence-specific single-stranded DNA-binding protein Pur alpha.
J Virol. 1996 Jun;70(6):4150-6.
PMID:8648759

Microbial origin of other chronic inflammatory conditions?

Oct 3, 2005 The Nobel Assembly at Karolinska Institutet Awards Prize

"Many diseases in humans such as Crohn's disease, ulcerative colitis, rheumatoid arthritis and atherosclerosis are due to chronic inflammation. The discovery that one of the most common diseases of mankind, peptic ulcer disease, has a microbial cause, has stimulated the search for microbes as possible causes of other chronic inflammatory conditions. Even though no definite answers are at hand, recent data clearly suggest that a dysfunction in the recognition of microbial products by the human immune system can result in disease development. The discovery of Helicobacter pylori has led to an increased understanding of the connection between chronic infection, inflammation and cancer." More

Inflammatory heart disease: A role for cytokines

Lupus. 2005;14(9):646-51.

Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.

Inflammatory heart disease is a rising concern worldwide. Similar mechanisms link autoimmune diseases, including the association of increased disease with pro inflammatory cytokines and the importance of regulatory mechanisms in the control of chronic inflammation. Many pathogens including bacteria, protozoa and viruses have been associated with heart disease in patients, and are able to induce similar disease in animal models. Recognition of pathogens by the innate immune system leads to release of pro inflammatory cytokines that both reduce infection and increase chronic inflammatory heart disease. Elevated levels of pro inflammatory cytokines are able to overcome tolerance to chronic disease, indicating that environmental factors are important in determining progression to chronic heart disease. Understanding the mechanisms leading to chronic heart disease will be critical for developing effective therapies to reduce cardiac dysfunction and heart failure.

The relevance of selenium to immunity, cancer, and infectious / inflammatory diseases

Cancer Journal Diet Pract Res. 2005 Summer;66(2):98-102.
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Selenium is an essential trace element involved in several key metabolic activities via selenoproteins, enzymes that are essential to protect against oxidative damage and to regulate immune function. Selenium also may have other health benefits unrelated to its enzymatic functions. It may provide important health benefits to people whose oxidative stress loads are high, such as those with inflammatory or infectious diseases like rheumatoid arthritis or human immunodeficiency virus/acquired immunodeficiency syndrome, or who are at high risk for cancers, particularly prostate cancer. Some studies have generated compelling evidence that selenium is beneficial, either alone or in conjunction with other micronutrients. Additional data from large clinical trials that provide the highest level of evidence will be key to determining the benefits accrued at various selenium intake levels. When the strength of the evidence becomes sufficient, clinical health professionals will need to use dietary and clinical assessment methods to ensure that people at increased risk for cancer or inflammatory and infectious diseases can be appropriately advised about selenium intake.

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