Andrographis paniculata research
Page updated: 10-22-2004
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Andrographis paniculata research
Andrographis Paniculata

Andrographis paniculata extract is traditionally used as a medicine to treat different diseases in India, China and Southeast Asia.


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 Current Andrographis Paniculata Research
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1: Kumar RA, Sridevi K, Kumar NV, Nanduri S, Rajagopal S. Related Articles
Abstract Anticancer and immunostimulatory compounds from Andrographis paniculata.
J Ethnopharmacol. 2004 Jun;92(2-3):291-5.
PMID: 15138014 [PubMed - indexed for MEDLINE]
2: Spasov AA, Ostrovskij OV, Chernikov MV, Wikman G. Related Articles
Abstract Comparative controlled study of Andrographis paniculata fixed combination, Kan Jang and an Echinacea preparation as adjuvant, in the treatment of uncomplicated respiratory disease in children.
Phytother Res. 2004 Jan;18(1):47-53.
PMID: 14750201 [PubMed - indexed for MEDLINE]
3: Poolsup N, Suthisisang C, Prathanturarug S, Asawamekin A, Chanchareon U. Related Articles
Abstract Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials.
J Clin Pharm Ther. 2004 Feb;29(1):37-45. Review.
PMID: 14748896 [PubMed - indexed for MEDLINE]
4: Rajagopal S, Kumar RA, Deevi DS, Satyanarayana C, Rajagopalan R. Related Articles
Abstract Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata.
J Exp Ther Oncol. 2003 May-Jun;3(3):147-58.
PMID: 14641821 [PubMed - indexed for MEDLINE]
5: Singha PK, Roy S, Dey S. Related Articles
Abstract Antimicrobial activity of Andrographis paniculata.
Fitoterapia. 2003 Dec;74(7-8):692-4.
PMID: 14630176 [PubMed - indexed for MEDLINE]
6: Li W, Sun Y, Joseph J, Fitzloff JF, Fong HH, van Breemen RB. Related Articles
Abstract p-Hydroxybenzoic acid alkyl esters in Andrographis paniculata herbs, commercial extracts, and formulated products.
J Agric Food Chem. 2003 Jan 15;51(2):524-9.
PMID: 12517121 [PubMed - indexed for MEDLINE]
7: Panossian A, Davtyan T, Gukassyan N, Gukasova G, Mamikonyan G, Gabrielian E, Wikman G. Related Articles
Abstract Effect of andrographolide and Kan Jang--fixed combination of extract SHA-10 and extract SHE-3--on proliferation of human lymphocytes, production of cytokines and immune activation markers in the whole blood cells culture.
Phytomedicine. 2002 Oct;9(7):598-605.
PMID: 12487323 [PubMed - indexed for MEDLINE]
8: Gabrielian ES, Shukarian AK, Goukasova GI, Chandanian GL, Panossian AG, Wikman G, Wagner H. Related Articles
Abstract A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis.
Phytomedicine. 2002 Oct;9(7):589-97.
PMID: 12487322 [PubMed - indexed for MEDLINE]
9: Siti Najila MJ, Noor Rain A, Mohamad Kamel AG, Syed Zahir SI, Khozirah S, Lokman Hakim S, Zakiah I, Azizol AK. Related Articles
Abstract The screening of extracts from Goniothalamus scortechinii, Aralidium pinnatifidum and Andrographis paniculata for anti-malarial activity using the lactate dehydrogenase assay.
J Ethnopharmacol. 2002 Oct;82(2-3):239-42.
PMID: 12242001 [PubMed - indexed for MEDLINE]
10: Batkhuu J, Hattori K, Takano F, Fushiya S, Oshiman K, Fujimiya Y. Related Articles
Free Full Text Suppression of NO production in activated macrophages in vitro and ex vivo by neoandrographolide isolated from Andrographis paniculata.
Biol Pharm Bull. 2002 Sep;25(9):1169-74.
PMID: 12230111 [PubMed - indexed for MEDLINE]
11: See D, Mason S, Roshan R. Related Articles
Abstract Increased tumor necrosis factor alpha (TNF-alpha) and natural killer cell (NK) function using an integrative approach in late stage cancers.
Immunol Invest. 2002 May;31(2):137-53.
PMID: 12148949 [PubMed - indexed for MEDLINE]
12: Zhang XF, Tan BK. Related Articles
Abstract Anti-diabetic property of ethanolic extract of Andrographis paniculata in streptozotocin-diabetic rats.
Acta Pharmacol Sin. 2000 Dec;21(12):1157-64.
PMID: 11603293 [PubMed - indexed for MEDLINE]
13: Zaridah MZ, Idid SZ, Omar AW, Khozirah S. Related Articles
Abstract In vitro antifilarial effects of three plant species against adult worms of subperiodic Brugia malayi.
J Ethnopharmacol. 2001 Nov;78(1):79-84.
PMID: 11585692 [PubMed - indexed for MEDLINE]
14: Singh RP, Banerjee S, Rao AR. Related Articles
Abstract Modulatory influence of Andrographis paniculata on mouse hepatic and extrahepatic carcinogen metabolizing enzymes and antioxidant status.
Phytother Res. 2001 Aug;15(5):382-90.
PMID: 11507728 [PubMed - indexed for MEDLINE]
15: Mandal SC, Dhara AK, Maiti BC. Related Articles
Abstract Studies on psychopharmacological activity of Andrographis paniculata extract.
Phytother Res. 2001 May;15(3):253-6.
PMID: 11351363 [PubMed - indexed for MEDLINE]
16: Burgos RA, Aguila MJ, Santiesteban ET, Sanchez NS, Hancke JL. Related Articles
Abstract Andrographis paniculata (Ness) induces relaxation of uterus by blocking voltage operated calcium channels and inhibits Ca(+2) influx.
Phytother Res. 2001 May;15(3):235-9.
PMID: 11351359 [PubMed - indexed for MEDLINE]
17: Panossian A, Hovhannisyan A, Mamikonyan G, Abrahamian H, Hambardzumyan E, Gabrielian E, Goukasova G, Wikman G, Wagner H. Related Articles
Abstract Pharmacokinetic and oral bioavailability of andrographolide from Andrographis paniculata fixed combination Kan Jang in rats and human.
Phytomedicine. 2000 Oct;7(5):351-64.
PMID: 11081986 [PubMed - indexed for MEDLINE]
18: Melchior J, Spasov AA, Ostrovskij OV, Bulanov AE, Wikman G. Related Articles
Abstract Double-blind, placebo-controlled pilot and phase III study of activity of standardized Andrographis paniculata Herba Nees extract fixed combination (Kan jang) in the treatment of uncomplicated upper-respiratory tract infection.
Phytomedicine. 2000 Oct;7(5):341-50.
PMID: 11081985 [PubMed - indexed for MEDLINE]
19: Burgos RA, Imilan M, Sanchez NS, Hancke JL. Related Articles
Abstract Andrographis paniculata (Nees) selectively blocks voltage-operated calcium channels in rat vas deferens.
J Ethnopharmacol. 2000 Jul;71(1-2):115-21.
PMID: 10904154 [PubMed - indexed for MEDLINE]
20: Zhang XF, Tan BK. Related Articles
Abstract Antihyperglycaemic and anti-oxidant properties of Andrographis paniculata in normal and diabetic rats.
Clin Exp Pharmacol Physiol. 2000 May-Jun;27(5-6):358-63.
PMID: 10831236 [PubMed - indexed for MEDLINE]
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Multiple vitamin-mineral (for elderly people)

Vitamin E (for elderly people)

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Acidophilus

Beta-carotene

Fish oil (omega-3 fatty acids for critically ill and post surgery patients only)

Glutamine (prevention of post-exercise infection in performance athletes)

Selenium (for elderly people)

Thymus extracts

Vitamin A

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Zinc (for elderly people)

Ashwa-
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Zinc (for non-elderly people)

Astragalus

Cat's claw

Fo-ti

Green tea

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••• Reliable and relatively consistent scientific data showing a substantial health benefit.

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Echinacea tea blend shortens duration of cold symptoms

In a double-blind, placebo-controlled clinical study of 95 people, treatment with an echinacea tea preparation (Echinacea Plus®, Traditional Medicinals) early in the course of a cold or flu was significantly more effective in relieving symptoms than a placebo tea. For the 90-day study, participants reported for assignment to one of two treatment groups at the first onset of cold and flu symptoms (scratchy throat, runny nose, fever, etc.). The subjects drank 5 to 6 cups a day of echinacea or placebo tea on the first day of symptoms, reducing the dosage to 1 cup per day for the next five days. Results were assessed with a questionnaire that measured symptom relief, duration of symptoms, and time before subjects noticed a difference in symptoms. The echinacea tea was significantly more effective than placebo in all parameters measured. No side effects were reported in either group. Echinacea Plus is a proprietary blend of E. purpurea and E. angustifolia leaves, flowers, and stems, a water soluble dry extract of E. purpurea root, and flavoring herbs. Eater's Digest® (Traditional Medicinals) was selected as the placebo tea because it was not expected to have a significant effect on cold or flu symptoms at the dosages used in this study. Among other herbs, Eater's Digest contains cinnamon, ginger, and peppermint. Lindenmuth GF, Lindenmuth EB.

The efficacy of echinacea compound herbal tea preparation on the severity and duration of upper respiratory and flu symptoms: a randomized, double-blind placebo-controlled study.

This article originally appeared in The Journal of Alternative and Complementary Medicine 2000; 6(4): 327-334.

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